RUPP surgery causes miscarriages and embryonic growth restriction.

<p>(<b>A</b>) Continuing pregnancies with or without the ligation at 14.5 dpc; parentheses show number of pregnancies at 14.5 dpc. (<b>B</b>) Embryo survival from 14.5 dpc to 18.5 dpc. (<b>C</b>) Representative images of embryos. Bars, 1 cm. (<b>D</b>) Embryonic weight at 18.5 dpc; parentheses show number of embryos/number of dams. (<b>E</b>) Placental weight at 18.5 dpc. (<b>F</b>) Embryonic weight/placental weight ratios. (<b>G</b>) Relationship between resorption rate and embryonic position in the uterus. (<b>H</b>) Relationship between embryonic weight and position in the uterus. Embryonic position was numbered from the position of ligation.