Cell viability significantly decreased in cadmium-transformed clones after 72 hour treatment with TMZ.

<p>(A) Cytotoxicity of TMZ on BEAS-2B cells after 24 hours as measured using the MTT assay. Data represents cells seeded in triplicate wells. (B) TMZ treatment decreased viability of cadmium clones relative to control clones after 72 hour treatment with TMZ. By 72 hours, BEAS-2B and control clones nearly restored to normal levels, while cadmium clone viability decreased steadily over time, indicating diminished ability to repair alkylated damage induced by TMZ. **p < 0.01 for all cadmium clones versus control clones after 72 hour TMZ treatment. Data represents three control clones and seven cadmium clones seeded in triplicate wells.