Mutation and neoantigen loads in the human HGSC and lung cancer TCGA datasets.

<p>Individual cases are aligned on the X axes in rank order according to the total number of mutations identified by whole exome sequencing (panel A); the same order of cases was used in panels B and C. Y axes indicate the number of mutations meeting the indicated criteria for each panel. Lung cancer cases (n = 603) are shown as solid black triangles, whereas HGSC cases (n = 274) are shown as hollow circles. <b>A.</b> Somatic, non-synonymous mutations identified by whole exome sequencing (total mutations). <b>B.</b> Somatic, non-synonymous mutations with at least one corresponding read in the RNA-seq data (transcribed mutations). <b>C.</b> Peptides predicted to bind autologous <i>HLA-A</i> with an IC50 < 100nM and containing somatic, non-synonymous, transcribed mutations. Only samples with unambiguous <i>HLA-A</i> allele calls are shown (lung n = 158, HGSC n = 220).