Neither <i>Pkd2</i> nor <i>Pkd2l1</i> is required for hair cell mechanotransduction.

<p><b>(a)</b><i>In situ</i> hybridization in cochlear sections. (<i>Left</i>) no label is evident with a control sense probe. (<i>Middle</i>) no specific label is evident in the <i>Pkd2l1</i> knockout. (<i>Right</i>) <i>In situ</i> hybridization with an antisense probe shows label of inner hair cells (arrowhead), outer hair cells (arrows) and inner sulcus cells (asterisks) in the organ of Corti. Scale bar = 50 μm; age P2. <b>(b)</b> ABR thresholds in response to pure tone stimuli. <i>Pkd2l1</i>^-/- mice show normal hearing at age P31-P37. <b>(c)</b> <i>Pkd2</i>^-/-:<i>Atoh1</i>-Cre^+/-mice show normal hearing at age 4~6 weeks. Data are mean ± sem; n as indicated.