Effects of CD36 deficiency on glucose metabolism parameters.

<p>A) Glucose tolerance test (GTT) in overnight fasted control lean (Lean), leptin null (Lep^ob/ob) and leptin and CD36 double null (Lep^ob/obCD36^-/-) mice. B) Insulin tolerance test (ITT) in 4-h fasted mice. C) Uptake of ¹⁸F-2-FDG in organs of overnight fasted mice. Mice were injected with 5 μCi of ¹⁸F-2-FDG in a lateral tail vein and glucose uptake in indicated organ was determined as described in the Methods. Results are presented as mean ± SEM (n = 5–7 per group). For GTT and ITT, statistical differences between initial time (0 min) and subsequent time points (after glucose and insulin injection) were performed by repeated measurement ANOVA test. Differences between groups Tukey’s and student t tests. Statistical significance between Lep^ob/ob and Lean mice are indicated with asterisks ** p < 0.01, and * p < 0.05. Significance between Lep^ob/ob CD36^-/- and Lep^ob/ob mice are indicated with alphabetic letters with ^a p < 0.001, ^b p < 0.01 and ^b p < 0.05. Statistical significance between Lep^ob/ob CD36^-/- and Lean mice are indicated with a capital alphabetic letter ^A p < 0.01.