<p>(A) Metabolic activity after extended hypoxia. Reducing activity was determined with XTT. Data are shown in arbitrary units. (B) The ratio of NADH to NAD. (C) Oxygen consumption was measured by methylene blue decolorization. (D) ATP levels in arbitrary units normalized to cell number. Black circles–WT, green squares–RVW7, red triangles–RVW7 pAld-Gen21. Asterisks indicate statistical significance (p<0.05) of the comparison of RVW7 with WT.</p
The bioenergetic mechanisms by which Mycobacterium tuberculosis survives hypoxia are poorly understo...
<p>Our metabolic network model predicted different adjustments in the biomass composition of wild ty...
<p>Cultures were grown for 600 hrs in the Wayne model, diluted in fresh media and then grown with vi...
<p>(A) The predicted normalized oxygen uptake rates of <i>Mycobacterium tuberculosis</i> H37Rv and t...
<p>A) <i>M. tuberculosis</i> transformants harbouring P<sub>278</sub> were grown in aerobic culture....
<p><i>M. tuberculosis</i> H37Rv bacteria were incubated under hypoxia and at pH 6.6 (open bar) or pH...
<p>Membrane potential in mV of <i>M. tuberculosis</i> strains at OD<sub>600</sub> 0.5 (aerobiosis), ...
<p>The solid vertical bars indicate the wild type normoxic- and hypoxic-normalized oxygen uptake rat...
<p>The left panel shows the flux ratios, i.e., the ratios of reaction fluxes under hypoxia to those ...
<div><p>The ability to adapt to different conditions is key for <em>Mycobacterium tuberculosis</em>,...
ABSTRACT: Growing evidence suggests that the presence of a subpopulation of hypoxic non-replicating,...
The ability to adapt to different conditions is key for Mycobacterium tuberculosis, the causative ag...
<p>Promoter activity was assayed in the hypoxia model using (A) LacZ and (B) mCherry as a reporter. ...
<p>A: Glyoxylate reductive aminase activity. B: pyruvate reductive aminase activity. C:isocitrate ly...
<p>(A) Respiratory kinetics were examined by monitoring dissolved oxygen (DO) consumption <i>of M. t...
The bioenergetic mechanisms by which Mycobacterium tuberculosis survives hypoxia are poorly understo...
<p>Our metabolic network model predicted different adjustments in the biomass composition of wild ty...
<p>Cultures were grown for 600 hrs in the Wayne model, diluted in fresh media and then grown with vi...
<p>(A) The predicted normalized oxygen uptake rates of <i>Mycobacterium tuberculosis</i> H37Rv and t...
<p>A) <i>M. tuberculosis</i> transformants harbouring P<sub>278</sub> were grown in aerobic culture....
<p><i>M. tuberculosis</i> H37Rv bacteria were incubated under hypoxia and at pH 6.6 (open bar) or pH...
<p>Membrane potential in mV of <i>M. tuberculosis</i> strains at OD<sub>600</sub> 0.5 (aerobiosis), ...
<p>The solid vertical bars indicate the wild type normoxic- and hypoxic-normalized oxygen uptake rat...
<p>The left panel shows the flux ratios, i.e., the ratios of reaction fluxes under hypoxia to those ...
<div><p>The ability to adapt to different conditions is key for <em>Mycobacterium tuberculosis</em>,...
ABSTRACT: Growing evidence suggests that the presence of a subpopulation of hypoxic non-replicating,...
The ability to adapt to different conditions is key for Mycobacterium tuberculosis, the causative ag...
<p>Promoter activity was assayed in the hypoxia model using (A) LacZ and (B) mCherry as a reporter. ...
<p>A: Glyoxylate reductive aminase activity. B: pyruvate reductive aminase activity. C:isocitrate ly...
<p>(A) Respiratory kinetics were examined by monitoring dissolved oxygen (DO) consumption <i>of M. t...
The bioenergetic mechanisms by which Mycobacterium tuberculosis survives hypoxia are poorly understo...
<p>Our metabolic network model predicted different adjustments in the biomass composition of wild ty...
<p>Cultures were grown for 600 hrs in the Wayne model, diluted in fresh media and then grown with vi...