MOESM1 of Tyrosine 625 plays a key role and cooperates with tyrosine 630 in MPL W515L-induced signaling and myeloproliferative neoplasms

Additional file 1. Figure S1. MPL W515L induces megakaryocyte hyperproliferation in vitro and causes myeloproliferative neoplasm in vivo. Figure S2. Cell proliferation and signaling in G1ME cells transduced with various MPL mutants in the presence of TPO. Figure S3. The effect of STAT3-deficiency on megakaryopoiesis. Figure S4. The effect of STAT3 ectopic expression on the megakaryopoiesis. Figure S5. Flow cytometry analysis of BM cells from the recipient mice. Figure S6. Inactivating specific signaling pathway was not enough to suppress hyperproliferation induced by MPL W515L