IL-1Ra treatment does not alleviate muscle pathology in <i>mdx</i> mice.

<p>Degenerating (A) and regenerating (B) muscle fibers were quantified in gastrocnemius muscle. Inflammatory cells were also quantified in sections from saline- and IL-1Ra-treated mice (C). Nuclei from sections were scored and quantified as either centralized (D) or peripheral (E). The number of fibers with centralized nuclei (F) was quantified by treatment group Values in the graphs represent mean ± SEM. Statistical significance was determined by parametric, unpaired, two-tailed, t-tests (N = 5, saline; N = 9, IL-1Ra).