Molecular dynamics (MD) simulated end structures of tubulin 1SA0 and tubulin isotypes.

<p>The positions of DAMA-colchicine before and after simulation are shown for comparison. The colour scheme for αβ-tubulin and DAMA-colchicine is same as for the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0156048#pone.0156048.g003" target="_blank">Fig 3</a>. Initial docked conformation of DAMA-colchicine (before simulation) shown in magenta colour while DAMA-colchicine after simulation is shown in green colour similar to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0156048#pone.0156048.g003" target="_blank">Fig 3</a>. (A) Tubulin 1SA0 and DAMA-colchicine complex. (B) αβ_II tubulin isotype-DAMA-colchicine complex. (C) αβ_III tubulin isotype-DAMA-colchicine complex (D) αβ_IV tubulin isotype-DAMA-colchicine complex. It is observed after simulation that the DAMA-colchicine moves away from the initial position in αβ_III tubulin isotype.