Examples of the effect of sodium ibuprofen on melanoma invasion.

<p><b>Wounded skin constructs.</b> (A and B) DED+F+K+HBL cells (10x and 40x magnifications respectively); (C and D) F+K+HBL cells+100μM NaIbu in media (10x and 40x magnifications respectively); (E) constructs containing DED+F+K+A375SM that have been wounded and a fibrin clot placed in the wound and which have also received TNF- α (300U/ml) (10x magnification); (F) A375SM Melanoma skin construct to which were added fibrin clots plus TNF-α (300U/ml) and a further treatment with 100μM NaIbu hydrogel (30μl volume), (10x magnification); (G) Effects of NaIbu hydrogel on wound healing of wounded melanoma skin constructs, DED+F+K+C8161; (H) F+K+C8161+NaIbu hydrogel 131μM (10x magnification). The site of the wound is indicated by an arrow. (DED = De-Epidermised acellular Dermis, F = Fibroblasts, K = Keratinocytes, W = Wound).