Modulation of CD24 expression directly affects the gene expression of various pro-survival genes critical in cisplatin resistance.

<p>A) and B) Down regulation of CD24 in CD24 rich UM-SCC-10B and UM-SCC-15s leads to significant down regulation of critical pro-survival genes, standard error of mean (t-test, n = 3). C) Up regulation of CD24 in CD24 deficient UM-SCC-74B leads to significant up regulation of critical pro-survival genes, standard error of mean (t-test, n = 3). D) Graph of the number of orospheres formed by the CD24 knockdown variants of UM-SCC-10B and UM-SCC-15s before and after an IC-50 dose of cisplatin treatment, standard error of mean (t-test, n = 3). E) Graph of the number of orospheres formed by the CD24 overexpressing variants of UM-SCC-74B before and after an IC-50 dose of cisplatin treatment, standard error of mean (t-test, n = 3).