TNF-α and IFN-γ primed iNOS Gene Expression Dynamics.

<p>The model was simulated with TNF-α, IFN-γ, or both TNF-α /IFN-γ for 24 simulation hours to prime the system. The concentrations of iNOS transcription factors, iNOS mRNA, and iNOS protein were used as inputs to the system for an 8-hour addition simulation under LPS activation. The resulting dynamics display the behavior of iNOS gene expression under primed conditions. The combination of both, TNF-α and IFN-γ causes a significant increase in the dynamics of the primed system however, IFN-γ priming has the ability to generate an increase in the proinflammatory burst when compared to the initial value of iNOS gene expression after IFN-γ priming.