Additional file 7: Figure S6. of Evolutionary origin and functional divergence of totipotent cell homeobox genes in eutherian mammals

Analysis of cow orthologues of human profile 27 genes. Nested circles show that of the 50 genes in human expression profile 27 and also affected by ETCHbox expression, 46 genes have orthologues in cow and of these 33 are expressed between oocyte and blastocyst in cow. Mfuzz clustering of the expression profiles of the 33 genes gave five profiles of which three are similar to human profile 27 with peak expression at 8-cell and/or 16-cell stages (clusters A, B, C). These three profiles contain the 19 bovine genes listed. GV, Germinal vesicle; MII, metaphase II oocyte; 4C, 4-cell; 8C, 8-cell; Bl, blastocyst. (PDF 346 kb