Skeletal and cardiac muscle in adults with growth hormone deficiency

The early descriptions of the physical capacities of adults with Growth Hormone (GH) deficiency (GHD) appeared in the late 1980s and early 1990s, highlighting reductions in skeletal muscle mass and force generation, aerobic exercise capacity, and cardiac muscle mass and function. This review will attempt to highlight recent understandings of the mechanisms underlying these abnormalities and the results of GH replacement therapy