CpG specific odds ratios were calculated between MS (n = 51) patients and Healthy controls (n = 137 for LINE-1 and SAT-Îą; n = 135 for Alu). Methylation was assessed in 3 CpG sites for Alu and SAT-Îą and 4 CpG sites in LINE-1. Estimates are presented as odds ratios, adjusted for age, gender and smoking status, and were calculated using the multivariate logistic regression analysis. (DOCX 564 kb
Supplemental methods, Table S1. CpGs from KORA EWAS. Those CpGs with a false discovery rate P < 0.15...
Methylation levels of various genomic features in autosomes. Mean methylation levels (%) of CpG cyto...
Number of detected CpG-sites per mean genome coverage. Figure S2. Overall CpG-site methylation level...
Characteristics of Multiple Sclerosis (MS) patients and healthy controls for each methylation marker...
Significant CpGs within hypermethylated DMRs are enriched for sites associated with aging in control...
Comparison of AD-associated methylation changes between two datasets generated from the STG. We comp...
Additional file 1: Supplementary Figure 1. Forest plots for the 5 most significant CpGs in female sa...
Table S1. Primers utilized in this study. Table S2. Methylation levels (β-values) of each CpG site ...
Figure S3. Comparison of all methods for inferring CpG methylation levels based on DNA enrichment da...
Sequencing statistics summary. Table S2. Genome feature association of filtered variant-removed CpGs...
Whole genome methylation in MMC patients versus controls. Unsupervised hierarchical clustering analy...
Longitudinal regression coefficients for each CpG site under investigation longitudinally, TSQL cate...
Table S4. Comparison of levels of p38MAPK, Erk1/2, STAT1, and STAT6 between MS patients and controls...
Materials and methods. Table S1. Primer sequences. Table S2. Clonality detected in the two patients ...
Table S1. Logistic regression analyses for single predictors. Highlighted in bold are p values for w...
Supplemental methods, Table S1. CpGs from KORA EWAS. Those CpGs with a false discovery rate P < 0.15...
Methylation levels of various genomic features in autosomes. Mean methylation levels (%) of CpG cyto...
Number of detected CpG-sites per mean genome coverage. Figure S2. Overall CpG-site methylation level...
Characteristics of Multiple Sclerosis (MS) patients and healthy controls for each methylation marker...
Significant CpGs within hypermethylated DMRs are enriched for sites associated with aging in control...
Comparison of AD-associated methylation changes between two datasets generated from the STG. We comp...
Additional file 1: Supplementary Figure 1. Forest plots for the 5 most significant CpGs in female sa...
Table S1. Primers utilized in this study. Table S2. Methylation levels (β-values) of each CpG site ...
Figure S3. Comparison of all methods for inferring CpG methylation levels based on DNA enrichment da...
Sequencing statistics summary. Table S2. Genome feature association of filtered variant-removed CpGs...
Whole genome methylation in MMC patients versus controls. Unsupervised hierarchical clustering analy...
Longitudinal regression coefficients for each CpG site under investigation longitudinally, TSQL cate...
Table S4. Comparison of levels of p38MAPK, Erk1/2, STAT1, and STAT6 between MS patients and controls...
Materials and methods. Table S1. Primer sequences. Table S2. Clonality detected in the two patients ...
Table S1. Logistic regression analyses for single predictors. Highlighted in bold are p values for w...
Supplemental methods, Table S1. CpGs from KORA EWAS. Those CpGs with a false discovery rate P < 0.15...
Methylation levels of various genomic features in autosomes. Mean methylation levels (%) of CpG cyto...
Number of detected CpG-sites per mean genome coverage. Figure S2. Overall CpG-site methylation level...