Steady-state characteristics and time constants of the <i>L-type</i> and <i>T-type</i> Ca²⁺ currents (<i>I</i>_<i>CaL</i> and <i>I</i>_<i>CaT</i>, respectively).

<p><b>A,</b> steady-state activation (<i>d</i>_<i>∞</i>) and voltage-dependent inactivation (<i>f</i>_<i>∞</i>) curves of <i>I</i>_<i>CaL</i>. <b>B,</b> activation time constant (<i>τ</i>_<i>d</i>) of <i>I</i>_<i>CaL</i>. <b>C,</b> inactivation time constant (<i>τ</i>_<i>f</i>) of <i>I</i>_<i>CaL</i>. <b>D,</b> Ca²⁺-dependent steady-state inactivation (<i>f</i>_<i>Ca∞</i>) curve of <i>I</i>_<i>CaL</i>. <b>E,</b> steady-state activation (<i>b</i>_<i>∞</i>) and inactivation (<i>g</i>_<i>∞</i>) curves of <i>I</i>_<i>CaT</i>. <b>F,</b> activation (<i>τ</i>_<i>b</i>) and inactivation (<i>τ</i>_<i>g</i>) time constants of <i>I</i>_<i>CaT</i>. <b>G,</b> normalized <i>I-V</i> curve for <i>I</i>_<i>CaL</i> and (<b>H)</b> normalized <i>I-V</i> curve for <i>I</i>_<i>CaT</i>. Black lines represent data generated using the model, whereas open circles and squares represent data derived from patch-clamp experiments of Avila et al. [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004946#pcbi.1004946.ref039" target="_blank">39</a>]