Epigenetic regulation of Nedd9 gene during osteoclastogenesis.
- Yasunori Omata (2851343)
- Shinya Nakamura (97647)
- Takuma Koyama (2851358)
- Tetsuro Yasui (2851340)
- Jun Hirose (649660)
- Naohiro Izawa (2851355)
- Takumi Matsumoto (2851352)
- Yuuki Imai (2851361)
- Sachiko Seo (2851346)
- Mineo Kurokawa (2851349)
- Shuichi Tsutsumi (200265)
- Yuho Kadono (122128)
- Chikao Morimoto (290914)
- Hiroyuki Aburatani (162634)
- Takeshi Miyamoto (163168)
- Sakae Tanaka (35403)
Publication date
June 2016
DOIAbstract
<p>(A) Smad2/3 binding and histone modification changes of <i>Nedd9</i> gene during osteoclastogenesis. Histone modification patterns in BMMs changed from K4(+)K27(+) to K4(+)K27(-) patterns by TGF-ß and returned to K4(+)K27(+) patterns after RANKL treatment. (B) <i>Nedd9</i> mRNA expression after TGF-ß or RANKL stimulation. The expression increased by TGF-ß stimulation and was reduced after RANKL treatment. The expression remained at low levels in the presence of SB431542.</p
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