Diagram of the brain network analysis.

<p>T1-weighted anatomical MRI scans of each individual were used to parcellate the cortex into 144 brain regions, forming the nodes of a brain network. Whole brain fiber tractography was applied to the DTI scans to reconstruct white matter pathways connecting pairs of brain regions, and the network edge was defined by the fiber density between the regions. The structural network was constructed in the form of a 144 × 144 weighted symmetric connectivity matrix. The topological organization of the resulting brain networks, including the correlations with blood glucose level (HbA1c and FPG), was investigated for 20 persons with type 2 diabetes and their age- and sex-matched controls.