B-cell and functional antibody responses after seasonal influenza vaccination.

<p>(<b>A</b>) Absolute number of plasmablasts (CD19⁺CD20^- CD38⁺) in 10⁶ live PBMCs acquired. (<b>B</b>) HI Geometric mean titers (GMT) for A H1N1 and H3N2, and B influenza strains at baseline (D0), 7 days (D7), 28 days (D28), and 168 days (D168) after a single dose of influenza vaccine. Data show three cohorts: saline placebo (n=7), TIIV (n=18), and ATIIV (n=17). (<b>C</b>) Geometric mean ratio (GMR) for all vaccine strains. Non-parametric Wilcoxon’s signed rank test was used for statistical analyses: *<i>p</i> < 0.05, **<i>p</i> < 0.01, and ***<i>p</i> < 0.001 compared to day 0; ^§<i>p</i> < 0.05, ^§§<i>p</i> < 0.01 and ^§§§<i>p</i> < 0.001 compared to saline placebo.