Reduction in Fibrosis.

<p>(A) Representative micrographs of Sirius red-stained liver sections in the rat TAA model (early intervention and established fibrosis; 100x), mouse NASH model (200x) and mouse UUO model (200x). (B) Reduction in collagen deposition in the rat TAA model (early intervention and established fibrosis), mouse NASH model^a and mouse UUO model^b. *<i>p</i> < 0.05 <i>vs</i>. sham control; **<i>p</i> < 0.01 <i>vs</i>. vehicle control; ***<i>p</i> < 0.001 <i>vs</i>. vehicle control; †<i>p</i> < 0.05 <i>vs</i>. UUO + vehicle control. ^aPerivascular area subtracted; ^bData presented exclude a single outlier from an animal in the CVC20 group, which had a CVF value >2 SDs higher than any other animal in the group. CVF, Collagen Volume Fraction; CVC, cenicriviroc; NASH, non-alcoholic steatohepatitis; SD, standard deviation; SEM, standard error of the mean; TAA, thioacetamide; UUO, unilateral ureteral obstruction.