Genome-wide chromatin and gene expression profiling during memory formation and maintenance in adult mice. [Data Record 5: MeDIP-seq]

<b><u>DESCRIPTION<br></u></b><u>Experiment type</u> - Methylation profiling by high throughput sequencing<br><u>Design</u> - Chromatin modification changes in two distinct mouse brain regions (CA1, ACC), two cell-types (NEU for neurons, NON for non-neurons) and three time-points (00H for naive, 01H for 1 hour, 04W for 4 weeks) before and after contextual learning (NAI for naive, CON for context, SHC for context shock).<br><br><u><b>DATA REPOSITORIES</b></u><br><u>EPIGENOME BROWSER (https://memory-epigenome-browser.dzne.de/)</u><br>Contains MedIP-seq data under category "MEDIP-DATA". Sample names include conditioning, time-point, tissue, cell type and replicate number (1 or 2; samples without numbers are merged replicates) separated by dashes. bigWig files can also be downloaded for local visualisation.<br><u>Gene Expression Omnibus (GEO)</u><br>Data is available on GEO under the accession number GSE74965 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE74965), containing SRA and bigWig files to download for all 40 MedIP-seq samples.<br><br><u><b>DATA GENERATION</b></u><br>Alignment and visualisation data was generate using the pre-processing code found in Figshare (https://dx.doi.org/10.6084/m9.figshare.3153193).<br><b><u><br></u>