Effects of model uncertainty on dynamical influence.

<p>A: The correlation between dynamical influence and evolutionary rate (dN/dS) is similarly strong in all models if dynamical influence is evaluated using all model molecular species (“full”) or only those deemed most important by the authors of the original study (“key”). B: Dynamical influences are strongly correlated between biologically-plausible rate constant sets for a model of EGF/NGF signaling [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006132#pgen.1006132.ref028" target="_blank">28</a>]. C: For that model and ensemble of rate constant sets, the correlation between dynamical influence and evolutionary rate varies in magnitude but is consistent in sign. D: Models with overlapping domains produce positively rank-correlated estimates of dynamical influence.