Exposure to caffeine-mixed alcohol attenuates caffeine-induced cocaine locomotor cross-sensitivity.

<p>Adolescent male animals exposured to water (H2O), 15 mg/kg caffeine (CAF), 1.5 g/kg alcohol (ALC), or caffeine-mixed alcohol (15 mg/kg caffeine, 1.5 g/kg alcohol, A+C) were challenged to 15 mg/kg cocaine in adulthood (n = 7–8 per group). Animals repeatedly exposed to caffeine alone exhibited increased cocaine locomotor cross-sensitization than animals exposed to water, alcohol, or caffeine-mixed alcohol. Significance by one-way ANOVA, *, p<0.05; data represented as mean ± SEM.