QTL mapping and haplotype analysis for survival against GAS NSTIs.

<p>(A) Genome-wide interval mapping of survival data (expressed as cRSI across BXD and parental strains) reveal a significant QTL on mouse Chr 2 (brown arrow). Red and gray horizontal lines indicate significant and suggestive LRS thresholds, respectively. (B) Haplotype analysis of the QTL region between 24.5 and 35 Mb on mouse Chr 2 is shown. BXD strains were rank-ordered on the basis of their cRSI values from susceptible to more resistant. Red and green bars (within each loci/position) indicate D and B alleles, respectively, whereas blue bars indicate heterozygous alleles. BXD cohorts harboring either D (red arrows) or B (green arrows) haplotypes within the QTL region and their parental strains selected for <i>in silico</i> validation analyses are indicated.