Salience network functional connectivity group difference map and its relationship with fatigue symptoms.

<p>Fig 1 difference map, subtracting adolescent CFS SN maps from healthy comparison (HC) SN maps, demonstrates less intrinsic SN connectivity to brain regions within the SN (right middle insula [R midINS], right posterior insula [R posINS], and right anterior insula [R antINS] <b>(left)</b>. Bar graph shows the mean and standard error Z scores for functional connectivity in each group <b>(middle)</b>. Right posterior insula connectivity strength decreases with greater fatigue symptoms in adolescent with Chronic Fatigue Syndrome but not with HC <b>(right)</b>. Dark circles represent individual patients with CFS and lighter circles represent HC participants. Activation height is thresholded at the <i>P</i> < 0.05 (corrected) level.