Covariation between salience network (SN) connectivity and pain intensity as assessed on functional magnetic resonance imaging.

<p>Fig 2 difference map, contrasting healthy comparison (HC) participants and adolescent patients with chronic fatigue syndrome (CFS), demonstrates a group interaction between pain intensity scores and intrinsic SN connectivity to the left (L) caudate and middle insula <b>(top).</b> The graphs contain connectivity Z scores and pain intensity scores, where dark circles represent individual patients with CFS and lighter circles represent HC participants <b>(bottom)</b>. Activation height is thresholded at the <i>P</i> < 0.05 (corrected) level.