<p>Cell toxicity assay of equimolar mixtures of the purified CDT subunits (as indicated) in the Jurkat cell line after 48 h incubation as described in Methods. Sub-picomolar toxic effects were only detected for the holotoxin with CdtB. Data are average of two independent experiments presented with standard error, each carried out in duplicate.</p
<p>A, Cytotoxic effects of DOX alone and DOX+LMB on cell viability of A549 cells as determined by th...
<p>AGS or AGS-BX1 cells were incubated with various concentrations of the hit compounds for 48h and ...
<p>The data represent the percentage of absorbance compared with the unexposed control cells. Bars a...
<p>Jurkat, HeLa, or CHO-A745 cells were seeded in clear-bottom 384-well plates, incubated overnight,...
<p>CHO-A745 cells were intoxicated as above in the presence or absence of 12.5 μM EGA. Additionally,...
<div><p>(A) Size exclusion chromatography of recombinant holotoxin containing different CdtC mutants...
<p>CHO-A745 cells were seeded at 8 x 10<sup>3</sup> cells/well on 96-well plates and allowed to adhe...
<p>Cells were treated with various compounds for 4h, and grown for another 20h. (A)IC50 of HeLa and ...
A. Representative images of γH2AX immunofluorescence and DAPI staining from HeLa cells treated with ...
Cytolethal distending toxin (CDT) is a multicomponent bacterial holotoxin that targets most eukaryto...
<p>(A) THP1 cells were intoxicated with titrations of the indicated purified toxins for 1 hour and L...
Cadmium (Cd) is a toxic heavy metal with no uniform mechanism of toxicity. In this the present study...
Cadmium (Cd) is a widespread environmental toxic contaminant, which causes serious health-related pr...
Cadmium (Cd) is a toxic heavy metal with no uniform mechanism of toxicity. In this the present study...
The replacement of animals in acute systemic toxicity testing remains a considerable challenge. Only...
<p>A, Cytotoxic effects of DOX alone and DOX+LMB on cell viability of A549 cells as determined by th...
<p>AGS or AGS-BX1 cells were incubated with various concentrations of the hit compounds for 48h and ...
<p>The data represent the percentage of absorbance compared with the unexposed control cells. Bars a...
<p>Jurkat, HeLa, or CHO-A745 cells were seeded in clear-bottom 384-well plates, incubated overnight,...
<p>CHO-A745 cells were intoxicated as above in the presence or absence of 12.5 μM EGA. Additionally,...
<div><p>(A) Size exclusion chromatography of recombinant holotoxin containing different CdtC mutants...
<p>CHO-A745 cells were seeded at 8 x 10<sup>3</sup> cells/well on 96-well plates and allowed to adhe...
<p>Cells were treated with various compounds for 4h, and grown for another 20h. (A)IC50 of HeLa and ...
A. Representative images of γH2AX immunofluorescence and DAPI staining from HeLa cells treated with ...
Cytolethal distending toxin (CDT) is a multicomponent bacterial holotoxin that targets most eukaryto...
<p>(A) THP1 cells were intoxicated with titrations of the indicated purified toxins for 1 hour and L...
Cadmium (Cd) is a toxic heavy metal with no uniform mechanism of toxicity. In this the present study...
Cadmium (Cd) is a widespread environmental toxic contaminant, which causes serious health-related pr...
Cadmium (Cd) is a toxic heavy metal with no uniform mechanism of toxicity. In this the present study...
The replacement of animals in acute systemic toxicity testing remains a considerable challenge. Only...
<p>A, Cytotoxic effects of DOX alone and DOX+LMB on cell viability of A549 cells as determined by th...
<p>AGS or AGS-BX1 cells were incubated with various concentrations of the hit compounds for 48h and ...
<p>The data represent the percentage of absorbance compared with the unexposed control cells. Bars a...