Temporal dynamics observed in mRNA and protein expression using the high-confidence set.
- Peter H. Waltman (3150789)
- Jian Guo (191157)
- Emily Nahas Reistetter (3150783)
- Samuel Purvine (3150786)
- Charles K. Ansong (3150792)
- Marijke J. van Baren (3150795)
- Chee-Hong Wong (21307)
- Chia-Lin Wei (18557)
- Richard D. Smith (39311)
- Stephen J. Callister (39306)
- Joshua M. Stuart (223220)
- Alexandra Z. Worden (588027)
Publication date
July 2016
DOIAbstract
<p><b>(A)</b> Comparison of absolute abundance values for the mRNA and protein expression data (all time points combined) indicates a moderate correlation between the data types (Spearman’s correlation coefficient, R<sub>S</sub> = 0.428, <i>p</i><0.0001). <b>(B)</b> Comparison of the log-ratios relative to T3 indicates a slightly negative correlation (R<sub>S</sub> = -0.168, <i>p</i><0.0001). These contrasting results suggest that while a relationship exists between mRNA and protein expression, there are considerable temporal differences between the respective expression programs.</p
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