Niclosamide inhibition of mitochondrial function is enhanced with acidic pH in PNEC cells.
- Joseph E. Ippolito (523145)
- Matthew W. Brandenburg (3149598)
- Xia Ge (2115646)
- Jan R. Crowley (13141)
- Kristopher M. Kirmess (3149595)
- Avik Som (1469344)
- D. Andre D’Avignon (3149601)
- Jeffrey M. Arbeit (159402)
- Samuel Achilefu (331507)
- Kevin E. Yarasheski (320459)
- Jeffrey Milbrandt (264401)
Publication date
July 2016
DOIAbstract
<p>(A) Kinetics of mitochondrial potential following addition of either vehicle (0.1% DMSO) or 10 μM niclosamide as a function of pH. (B) ATP levels in PNEC cells obtained 30 minutes following addition of either vehicle or 10 μM niclosamide. Significance calculated relative to pH 7.4 for panel A and relative to vehicle treatment for panel B. N = 10 samples per group for kinetics and N = 3 samples per group for ATP assay. ***p<0.001, ****p<0.0001. A.U.: arbitrary units.</p
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