Comparative immunogenicity of TV1.C and 1086.C gp120 monomers and dimers.
- Carlo Zambonelli (3149121)
- Antu K. Dey (172141)
- Susan Hilt (3149133)
- Samuel Stephenson (3149127)
- Eden P. Go (207858)
- Daniel F. Clark (471206)
- Mark Wininger (3149124)
- Celia Labranche (3149118)
- David Montefiori (161606)
- Hua-Xin Liao (161409)
- Ronald I. Swanstrom (3149130)
- Heather Desaire (207860)
- Barton F. Haynes (140266)
- Andrea Carfi (203340)
- Susan W. Barnett (120170)
Publication date
July 2016
DOIAbstract
<p>Rabbit immune sera collected post-3<sup>rd</sup> immunization were evaluated. Serum Ab binding titers (panel A) and avidities (panel B) elicited by monomeric and dimeric fractions of TV1.C and 1086.C gp120s. Strain matched gp120 proteins were used for the binding and avidity analyses. Virus neutralization ID50 titers elicitied by monomeric (solid symbols) and dimeric (open symbols) fractions of TV1.C (panel C) and 1086.C (panel D) against a tier 1 and tier 2 HIV-1 pseudoviruses. No statistically significant differences were observed.</p
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