Human genetic variation associated with infectious diseases and unintended consequences in autoimmunity and chronic disease.

<p>Infectious diseases are organized according to organism along the left. Lines connect infectious diseases to human genetic variants and are color coded grey if the genetic variant is not known to be associated with a non-infectious disease. If the same genetic variant is associated with both an infectious disease and one or more autoimmune, chronic, or malignant diseases, the line is given a non-grey color that allows the color to be traced from infectious disease to gene to non-infectious disease (for example, red lines connect from malaria to <i>ABO</i> to venous thromboembolism). Locations of genetic variants and the likely causal gene are represented by their locations along human chromosomes, represented by the middle set of boxes. Genetic variants were derived from the European Bioinformatics Institute-National Human Genome Research Institute (EBI-NHGRI) GWAS Catalog (p < 5 x 10⁻⁸) [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005680#ppat.1005680.ref038" target="_blank">38</a>] and from [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005680#ppat.1005680.ref039" target="_blank">39</a>,<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005680#ppat.1005680.ref040" target="_blank">40</a>]. The data used to construct this figure are in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005680#ppat.1005680.s001" target="_blank">S1 Table</a>.