CD8⁺ and CD4⁺ T cells are required for the antitumor response.

<p>(A) ID8DV ovarian tumors were established in wild-type or <i>CD8</i>^<i>-/-</i> C57BL/6 mice and groups of mice were treated with PBS or were vaccinated i.p. with tachyzoites of uracil auxotrophs (OMP) using the three-dose treatment schedule. (B-C) ID8DV ovarian tumors were established in C57BL/6 mice and groups of mice were treated with PBS or were vaccinated i.p. with tachyzoites of uracil auxotrophs (OMP) on day 8 and day 20. Groups of mice were treated with isotype control antibody, or (B) αCD8 antibody, or (C) αCD4 antibody on days 7, 8, 11, 19, 20, 23 after tumor challenge. Data is representative of two independent experiments. ns was not significant, **p<0.01, ***P<0.001, ****p<0.0001.