Additional file 2: of Vascular disruptive agent OXi4503 and anti-angiogenic agent Sunitinib combination treatment prolong survival of mice with CRC liver metastasis

OXi4503, Sunitinib and combination treatments induce EMT in the surviving tumor cells. Formalin-fixed control and treated tumor sections were stained with antibodies to E-cadherin, ZEB1, or Vimentin. Positive expression is detected by the brown staining. Scale bar = 200 mm. L = liver, T = live tumor. NT = necrotic tumor. Images are representative for each treatment group (n ≥ 5 animals). (PDF 417 kb