IL-1Ra and MCP-1 levels are significantly different between groups in severe cases.

<p>Box and whisker plots of circulating IL-1Ra (left panel) and MCP-1 (right panel) levels during the acute phase of dengue illness in CYD-TDV and placebo recipients: (A) irrespective of severity (CYD-TDV N = 99, Placebo N = 108); (B) in severe cases (CYD-TDV N = 24, Placebo N = 28); and (C) in non-severe cases (CYD-TDV N = 74, Placebo N = 80). The boundary of the box closest to zero indicates the 25th percentile, the line within the box marks the median, and the boundary of the box farthest from zero indicates the 75th percentile. Whiskers (error bars) above and below the box indicate the 90th and 10th percentiles. The individual points represent outliers. Values below the lower limit of quantification were replaced by half of the limit of quantification. Significant differences are indicated by *p < 0.05 and **p ≤ 0.01.