Increased tumor predisposition in <i>Brca2</i>^<i>G25R</i> hemizygous mice.

<p><b>A.</b> Median and average age of death, including number of mice per genotype analyzed (n) and shown by gender. <b>B.</b> Kaplan-Meier tumor-free survival curves of <i>Brca2</i> mutant animals (104 week study). <b>C.</b> Kaplan-Meier tumor-free survival curves of <i>Brca2</i> mutant mice on a <i>Trp53</i>^<i>Ko/+</i> genetic background (104 week study). <b>D.</b> and <b>E.</b> Distribution of tumor types found in mice of indicated genotypes. Abbreviations: NT = No tumor observed, BCL = B-cell lymphoma, TCL = T-cell lymphoma, HS = Histiocytic sarcoma, OS = Osteosarcoma, HemS = Hemangiosarcoma, OthSa = Other sarcomas, AD = Adenomas, OthCa = Other carcinomas, MT = Multiple tumors, UNK = cause of death unknown. * UNK are included in the tumor-free survival curves as potential neoplasias. Controls are represented by: Brca2^+/+ and Brca2^Ko/+. Abbreviations: Brca2^Ko/+ = <b>B2</b>^<b>Ko/+</b>, Brca2^G25R/+ = <b>B2</b>^<b>GR/+</b>, Brca2^G25R/G25R = <b>B2</b>^<b>GR/GR</b>, Brca2^G25R/Ko = <b>B2</b>^<b>GR/Ko</b>.