Mutational Biases Drive Elevated Rates of Substitution at Regulatory Sites across Cancer Types - Fig 5

<p>A) The number of mutations inside functional and control TFBSs, plotted for each tumour sample in this study. B) Cancer mutations in TF binding sites, stratified by tumour type. Heatmap of mutation counts in functional motifs, relative to control sites and 1KG polymorphisms. Only motifs that occur in at least 1,000 binding sites in the genome are shown, for the four tumour types with the highest total number of mutations. Increasing shades of red: ratio > 1, indicating an excess of functional mutations in cancer; grey: ratio <1.