S426A/S430A mutant mice have normal body weight.

<p>Body weight was measured each week for S426A/S430A mutant (red line and circles) and wild-type mice (WT; black line and squares) given HFD (<b>A</b>) or LFD (<b>B</b>) starting from weaning until 20 weeks of age. Data are expressed as mean ± S.E.M and were analyzed using two-way ANOVA. The number of animals tested in each group is indicated in parentheses.