Codon variability at HCV NS5A positions associated with major drug resistance to NS5A inhibitors and its impact on the genetic barrier to drug resistance development in HCV genotypes 1 to 3.

Subtype Specific Differences in NS5A Domain II Reveals Involvement of Proline at Position 310 in Cyclosporine Susceptibility of Hepatitis C Virus

Israr-ul Ansari

November 2012

Hepatitis C virus (HCV) is susceptible to cyclosporine (CsA) and other cyclophilin (CypA) inhibitors...

Amino acid diversity in the NS5B polymerase region of 77 G1a and 39 G1b isolates from treatment-naïve HCV infected subjects.

Severine Margeridon-Thermet (618708)
Sophie Le Pogam (618709)
Lewyn Li (168505)
Tommy F. Liu (374095)
Nancy Shulman (42411)
Robert W. Shafer (32534)
Isabel Najera (618710)

August 2014

Numbers in superscript represent the number of isolates with a particular noted residue. Amino ac...

Prevalence of baseline polymorphisms for potential resistance to NS5A inhibitors in drug-naive individuals infected with hepatitis C genotypes 1–4

McCormick, A.L.
Wang, L.
Garcia-Diaz, A.
Macartney, M.J.
Webster, D.P.
Haque, T.
McCormick, A.L.
Wang, L.
Garcia-Diaz, A.
Macartney, M.J.
Webster, D.P.
Haque, T.

January 2014

Background: The non-structural 5A (NS5A) protein of HCV is a multifunctional phosphoprotein involved...

Codon variability at HCV NS3 positions associated with minor drug resistance to PIs and its impact on the genetic barrier to drug resistance development in HCV-genotypes 1–6.

Valeria Cento (103603)
Carmen Mirabelli (152454)
Romina Salpini (152458)
Salvatore Dimonte (152462)
Anna Artese (152465)
Giosuè Costa (152469)
Fabio Mercurio (152471)
Valentina Svicher (103599)
Lucia Parrotta (152478)
Ada Bertoli (152483)
Marco Ciotti (152490)
Daniele Di Paolo (152495)
Cesare Sarrecchia (152500)
Massimo Andreoni (103649)
Stefano Alcaro (152511)
Mario Angelico (152517)
Carlo Federico Perno (103671)
Francesca Ceccherini-Silberstein (103660)

July 2012

aThe wild-type amino-acid of HCV genotype 1b at each position associated with drug resistance is ...

Codon variability at HCV NS3 positions associated with major drug resistance to PIs and its impact on the genetic barrier to drug resistance development in HCV-genotypes 1–6.

Valeria Cento (103603)
Carmen Mirabelli (152454)
Romina Salpini (152458)
Salvatore Dimonte (152462)
Anna Artese (152465)
Giosuè Costa (152469)
Fabio Mercurio (152471)
Valentina Svicher (103599)
Lucia Parrotta (152478)
Ada Bertoli (152483)
Marco Ciotti (152490)
Daniele Di Paolo (152495)
Cesare Sarrecchia (152500)
Massimo Andreoni (103649)
Stefano Alcaro (152511)
Mario Angelico (152517)
Carlo Federico Perno (103671)
Francesca Ceccherini-Silberstein (103660)

July 2012

aThe wild-type amino-acid of HCV genotype 1b at each position associated with drug resistance is ...

Frequency of consensus residues in hepatitis C virus genotypes 1 to 6: significance for DAA treatment and drug resistance

Cuypers, Lize
Li, Guangdi
Libin, Pieter
Vandamme, Anne-Mieke
Theys, Kristof

October 2015

Background In order to clear HCV in chronically infected patients, treatment with combinations of pa...

Frequency of Natural Resistance within NS5a Replication Complex Domain in Hepatitis C Genotypes 1a, 1b: Possible Implication of Subtype-Specific Resistance Selection in Multiple Direct Acting Antivirals Drugs Combination Treatment

Sabrina Bagaglio
Andrea Andolina
Marco Merli
Caterina Uberti-Foppa
Giulia Morsica

March 2016

Different HCV subtypes may naturally harbor different resistance selection to anti-NS5a inhibitors. ...

Genetic Barrier to Direct Acting Antivirals in HCV Sequences Deposited in the European Databank.

Dimas Alexandre Kliemann
Cristiane Valle Tovo
Ana Beatriz Gorini da Veiga
André Luiz Machado
John West

January 2016

Development of resistance results from mutations in the viral genome, and the presence of selective ...

Variability in codon usage in Coronaviruses is mainly driven by mutational bias and selective constraints on CpG dinucleotide

Daron Josquin

July 2021

Supplementary Figures and Tables for the article called: " Variability in codon usage in Coronavirus...

Hepatitis C virus genetic variability and the presence of NS5B resistance-associated mutations as natural polymorphisms in selected genotypes could affect the response to NS5B inhibitors

Di Maio, V
Cento, V
Mirabelli, C
Artese, A
Costa, G
Alcaro, S
Perno, C
Ceccherini-Silberstein, F

May 2014

Because of the extreme genetic variability of hepatitis C virus (HCV), we analyzed the NS5B polymera...

Genetic variability in the 5' UTR and NS5A regions of hepatitis C virus RNA isolated from non-responding and responding patients with chronic HCV genotype 1 infection

Ara??jo, Fl??vio Marcos Gomes
Sonoda, Ivan Vieira
Rodrigues, Nilton Barnabe
Teixeira, Rosangela
Redondo, Rodrigo AF
Oliveira, Guilherme Corr??a de

January 2008

Sequence variation among different hepatitis C virus (HCV) isolates has adaptive significance and re...

HCV genotypes are differently prone to the development of resistance to linear and macrocyclic protease inhibitors

Cento, V
Mirabelli, C
Salpini, R
DIMONTE, SALVATORE
ARTESE, ANNA
Costa, G
Mercurio, F
SVICHER, VALENTINA
Parrotta, L
BERTOLI, ADA
Ciotti, M
Di Paolo, D
SARRECCHIA, CESARE
ANDREONI, MASSIMO
Alcaro, S
ANGELICO, MARIO
PERNO, CARLO FEDERICO
CECCHERINI SILBERSTEIN, FRANCESCA

January 2012

Because of the extreme genetic variability of hepatitis C virus (HCV), we analyzed whether specific ...

Phenotypic analysis of NS5A variant from liver transplant patient with increased cyclosporine susceptibility

Ansari, Israr-ul H.
Allen, Todd
Berical, Andrew
Stock, Peter G.
Barin, Burc
Striker, Rob

February 2013

AbstractHepatitis C virus (HCV) replication is limited by cyclophilin inhibitors but it remains uncl...

Genetic Barrier to Direct Acting Antivirals in HCV Sequences Deposited in the European Databank

Kliemann, Dimas Alexandre
Tovo, Cristiane Valle
Beatriz Gorini da Veiga, Ana
Machado, André Luiz
West, John T.

January 2016

Background & Aims: Development of resistance results from mutations in the viral genome, and the pre...

Genetic variations occurring in long-term replication of genome-length HCV RNAs.

Nobuyuki Kato (235685)
Hiroe Sejima (535275)
Youki Ueda (452252)
Kyoko Mori (452254)
Shinya Satoh (54269)
Hiromichi Dansako (357935)
Masanori Ikeda (235684)

March 2014

(A) Genetic variations in the 5′-terminus-NS2 regions. The left vertical line indicates the mean ...

Subtype Specific Differences in NS5A Domain II Reveals Involvement of Proline at Position 310 in Cyclosporine Susceptibility of Hepatitis C Virus

Israr-ul Ansari

November 2012

Hepatitis C virus (HCV) is susceptible to cyclosporine (CsA) and other cyclophilin (CypA) inhibitors...

Amino acid diversity in the NS5B polymerase region of 77 G1a and 39 G1b isolates from treatment-naïve HCV infected subjects.

Severine Margeridon-Thermet (618708)
Sophie Le Pogam (618709)
Lewyn Li (168505)
Tommy F. Liu (374095)
Nancy Shulman (42411)
Robert W. Shafer (32534)
Isabel Najera (618710)

August 2014

Numbers in superscript represent the number of isolates with a particular noted residue. Amino ac...

Prevalence of baseline polymorphisms for potential resistance to NS5A inhibitors in drug-naive individuals infected with hepatitis C genotypes 1–4

McCormick, A.L.
Wang, L.
Garcia-Diaz, A.
Macartney, M.J.
Webster, D.P.
Haque, T.
McCormick, A.L.
Wang, L.
Garcia-Diaz, A.
Macartney, M.J.
Webster, D.P.
Haque, T.

January 2014

Background: The non-structural 5A (NS5A) protein of HCV is a multifunctional phosphoprotein involved...

Codon variability at HCV NS3 positions associated with minor drug resistance to PIs and its impact on the genetic barrier to drug resistance development in HCV-genotypes 1–6.

Valeria Cento (103603)
Carmen Mirabelli (152454)
Romina Salpini (152458)
Salvatore Dimonte (152462)
Anna Artese (152465)
Giosuè Costa (152469)
Fabio Mercurio (152471)
Valentina Svicher (103599)
Lucia Parrotta (152478)
Ada Bertoli (152483)
Marco Ciotti (152490)
Daniele Di Paolo (152495)
Cesare Sarrecchia (152500)
Massimo Andreoni (103649)
Stefano Alcaro (152511)
Mario Angelico (152517)
Carlo Federico Perno (103671)
Francesca Ceccherini-Silberstein (103660)

July 2012

aThe wild-type amino-acid of HCV genotype 1b at each position associated with drug resistance is ...

Codon variability at HCV NS3 positions associated with major drug resistance to PIs and its impact on the genetic barrier to drug resistance development in HCV-genotypes 1–6.

Valeria Cento (103603)
Carmen Mirabelli (152454)
Romina Salpini (152458)
Salvatore Dimonte (152462)
Anna Artese (152465)
Giosuè Costa (152469)
Fabio Mercurio (152471)
Valentina Svicher (103599)
Lucia Parrotta (152478)
Ada Bertoli (152483)
Marco Ciotti (152490)
Daniele Di Paolo (152495)
Cesare Sarrecchia (152500)
Massimo Andreoni (103649)
Stefano Alcaro (152511)
Mario Angelico (152517)
Carlo Federico Perno (103671)
Francesca Ceccherini-Silberstein (103660)

July 2012

aThe wild-type amino-acid of HCV genotype 1b at each position associated with drug resistance is ...

Frequency of consensus residues in hepatitis C virus genotypes 1 to 6: significance for DAA treatment and drug resistance

Cuypers, Lize
Li, Guangdi
Libin, Pieter
Vandamme, Anne-Mieke
Theys, Kristof

October 2015

Background In order to clear HCV in chronically infected patients, treatment with combinations of pa...

Frequency of Natural Resistance within NS5a Replication Complex Domain in Hepatitis C Genotypes 1a, 1b: Possible Implication of Subtype-Specific Resistance Selection in Multiple Direct Acting Antivirals Drugs Combination Treatment

Sabrina Bagaglio
Andrea Andolina
Marco Merli
Caterina Uberti-Foppa
Giulia Morsica

March 2016

Different HCV subtypes may naturally harbor different resistance selection to anti-NS5a inhibitors. ...

Genetic Barrier to Direct Acting Antivirals in HCV Sequences Deposited in the European Databank.

Dimas Alexandre Kliemann
Cristiane Valle Tovo
Ana Beatriz Gorini da Veiga
André Luiz Machado
John West

January 2016

Development of resistance results from mutations in the viral genome, and the presence of selective ...

Variability in codon usage in Coronaviruses is mainly driven by mutational bias and selective constraints on CpG dinucleotide

Daron Josquin

July 2021

Supplementary Figures and Tables for the article called: " Variability in codon usage in Coronavirus...

Hepatitis C virus genetic variability and the presence of NS5B resistance-associated mutations as natural polymorphisms in selected genotypes could affect the response to NS5B inhibitors

Di Maio, V
Cento, V
Mirabelli, C
Artese, A
Costa, G
Alcaro, S
Perno, C
Ceccherini-Silberstein, F

May 2014

Because of the extreme genetic variability of hepatitis C virus (HCV), we analyzed the NS5B polymera...

Genetic variability in the 5' UTR and NS5A regions of hepatitis C virus RNA isolated from non-responding and responding patients with chronic HCV genotype 1 infection

Ara??jo, Fl??vio Marcos Gomes
Sonoda, Ivan Vieira
Rodrigues, Nilton Barnabe
Teixeira, Rosangela
Redondo, Rodrigo AF
Oliveira, Guilherme Corr??a de

January 2008

Sequence variation among different hepatitis C virus (HCV) isolates has adaptive significance and re...

HCV genotypes are differently prone to the development of resistance to linear and macrocyclic protease inhibitors

Cento, V
Mirabelli, C
Salpini, R
DIMONTE, SALVATORE
ARTESE, ANNA
Costa, G
Mercurio, F
SVICHER, VALENTINA
Parrotta, L
BERTOLI, ADA
Ciotti, M
Di Paolo, D
SARRECCHIA, CESARE
ANDREONI, MASSIMO
Alcaro, S
ANGELICO, MARIO
PERNO, CARLO FEDERICO
CECCHERINI SILBERSTEIN, FRANCESCA

January 2012

Because of the extreme genetic variability of hepatitis C virus (HCV), we analyzed whether specific ...

Phenotypic analysis of NS5A variant from liver transplant patient with increased cyclosporine susceptibility

Ansari, Israr-ul H.
Allen, Todd
Berical, Andrew
Stock, Peter G.
Barin, Burc
Striker, Rob

February 2013

AbstractHepatitis C virus (HCV) replication is limited by cyclophilin inhibitors but it remains uncl...

Genetic Barrier to Direct Acting Antivirals in HCV Sequences Deposited in the European Databank

Kliemann, Dimas Alexandre
Tovo, Cristiane Valle
Beatriz Gorini da Veiga, Ana
Machado, André Luiz
West, John T.

January 2016

Background & Aims: Development of resistance results from mutations in the viral genome, and the pre...

Genetic variations occurring in long-term replication of genome-length HCV RNAs.

Nobuyuki Kato (235685)
Hiroe Sejima (535275)
Youki Ueda (452252)
Kyoko Mori (452254)
Shinya Satoh (54269)
Hiromichi Dansako (357935)
Masanori Ikeda (235684)

March 2014

(A) Genetic variations in the 5′-terminus-NS2 regions. The left vertical line indicates the mean ...

Subtype Specific Differences in NS5A Domain II Reveals Involvement of Proline at Position 310 in Cyclosporine Susceptibility of Hepatitis C Virus

Israr-ul Ansari

November 2012

Hepatitis C virus (HCV) is susceptible to cyclosporine (CsA) and other cyclophilin (CypA) inhibitors...

Amino acid diversity in the NS5B polymerase region of 77 G1a and 39 G1b isolates from treatment-naïve HCV infected subjects.

Severine Margeridon-Thermet (618708)
Sophie Le Pogam (618709)
Lewyn Li (168505)
Tommy F. Liu (374095)
Nancy Shulman (42411)
Robert W. Shafer (32534)
Isabel Najera (618710)

August 2014

Numbers in superscript represent the number of isolates with a particular noted residue. Amino ac...

Prevalence of baseline polymorphisms for potential resistance to NS5A inhibitors in drug-naive individuals infected with hepatitis C genotypes 1–4

McCormick, A.L.
Wang, L.
Garcia-Diaz, A.
Macartney, M.J.
Webster, D.P.
Haque, T.
McCormick, A.L.
Wang, L.
Garcia-Diaz, A.
Macartney, M.J.
Webster, D.P.
Haque, T.

January 2014

Background: The non-structural 5A (NS5A) protein of HCV is a multifunctional phosphoprotein involved...

Codon variability at HCV NS5A positions associated with major drug resistance to NS5A inhibitors and its impact on the genetic barrier to drug resistance development in HCV genotypes 1 to 3.

Abstract

Extracted data

Codon variability at HCV NS5A positions associated with major drug resistance to NS5A inhibitors and its impact on the genetic barrier to drug resistance development in HCV genotypes 1 to 3.

Abstract

Extracted data

Related items

Related items