Establishment of allergic airway inflammation.

<p>(a) Total BAL fluid cell numbers were increased after OVA exposure. (b) BAL fluid eosinophils as a percentage of total BAL cells were increased after OVA/OVA exposure as compared to OVA/PBS exposure, while macrophages were decreased. (c) Total B cells (B220⁺SSC^low), newly produced B cells during allergen exposure (B220⁺SSC^lowBrdU⁺) and immature B cells (B220⁺SSC^lowCD93⁺) in various biological compartments harvested upon allergen exposure. B cell precursor population significantly decreases in the BM after OVA exposure, and increases at the same time in the spleen, the lung and the BAL fluid. Data are presented as mean ± SEM, n = 5–8 mice/group, * <i>p</i> < 0.05, <i>i</i>.<i>p</i>.: intraperitoneally, <i>i</i>.<i>n</i>.: intranasally, <i>i</i>.<i>c</i>.: isotype control, ND: not detectable.