<p>Induction of GAL4 (OE) started at 1 week of age and flies were tested at 3 weeks of age (2 week treatment period) with 200μM of RU486. (<b>A</b>), Day Sleep bout number; (<b>B</b>), Day activity counts (per 12h period); (<b>C</b>), Total activity count (per 24h period); (<b>D</b>), Day activity (min per 12h); (<b>E</b>) Night activity (min per 12h) and (<b>F</b>) Total activity (min per24h)(**p<0.01, ***p<0.001, ****p<0.0001; SEM is indicated with n = 48 flies; Paired Student’s <i>t</i>-test).</p
(A and B) Rationale (A) and protocol (B) for immunochemistry examinations of fly brains of 0.1 mg ml...
<p>A) Averaged sleep profiles of control <i>iso31</i> (black) and <i>Nf1</i><sup><i>P1/P2</i></sup> ...
(A) Sleep profiles in R23E10>Dop1R1RNAi, flies and their parental controls R23E10/+, and Dop1R1RNAi/...
<p>(<b>A</b>, <b>B</b>) Double-plotted actograms of young flies (3 days after hatching) expressing w...
<p><b>CG10814 knockdown in the nervous tissue results in a rescue of age-dependent loss of sleep con...
<p>Male and female control flies (<i>w<sup>1118</sup>/+</i>) were aged, entrained and assayed betwee...
<p>(A) NF-κB reporter activity in multiple tissues oscillates in constant darkness. Reporter activit...
<p>(<b>A</b>): Lifespan of flies carrying two neuronal transgenes <i>G6PD</i> and <i>HQ93</i> (open ...
<div><p>Larvae and newly emerged adults were reared at 18°C, and newly emerged flies were entrained ...
(A-D) Sleep structure of 1xBRP female flies at age 20d rescued by a transgenic brp copy (gBRP) and a...
<p>(A) LD locomotor activity profile (average activity of three full days displayed over the 24 hour...
(A and B) Locomotor walking activity distribution across the day (A) and averaged daily total walkin...
<p>Fly activities (number of beam breaks) during Zeitgeber rhythm were recorded on the 3<sup>rd</sup...
<p>A) Panels depict the average daily locomotor activity for Aβ<sub>40</sub>, Aβ<sub>42</sub>, and G...
<p>*Flies were raised and entrained at 18. Their activities were monitored in DD at 18°C for 4 days ...
(A and B) Rationale (A) and protocol (B) for immunochemistry examinations of fly brains of 0.1 mg ml...
<p>A) Averaged sleep profiles of control <i>iso31</i> (black) and <i>Nf1</i><sup><i>P1/P2</i></sup> ...
(A) Sleep profiles in R23E10>Dop1R1RNAi, flies and their parental controls R23E10/+, and Dop1R1RNAi/...
<p>(<b>A</b>, <b>B</b>) Double-plotted actograms of young flies (3 days after hatching) expressing w...
<p><b>CG10814 knockdown in the nervous tissue results in a rescue of age-dependent loss of sleep con...
<p>Male and female control flies (<i>w<sup>1118</sup>/+</i>) were aged, entrained and assayed betwee...
<p>(A) NF-κB reporter activity in multiple tissues oscillates in constant darkness. Reporter activit...
<p>(<b>A</b>): Lifespan of flies carrying two neuronal transgenes <i>G6PD</i> and <i>HQ93</i> (open ...
<div><p>Larvae and newly emerged adults were reared at 18°C, and newly emerged flies were entrained ...
(A-D) Sleep structure of 1xBRP female flies at age 20d rescued by a transgenic brp copy (gBRP) and a...
<p>(A) LD locomotor activity profile (average activity of three full days displayed over the 24 hour...
(A and B) Locomotor walking activity distribution across the day (A) and averaged daily total walkin...
<p>Fly activities (number of beam breaks) during Zeitgeber rhythm were recorded on the 3<sup>rd</sup...
<p>A) Panels depict the average daily locomotor activity for Aβ<sub>40</sub>, Aβ<sub>42</sub>, and G...
<p>*Flies were raised and entrained at 18. Their activities were monitored in DD at 18°C for 4 days ...
(A and B) Rationale (A) and protocol (B) for immunochemistry examinations of fly brains of 0.1 mg ml...
<p>A) Averaged sleep profiles of control <i>iso31</i> (black) and <i>Nf1</i><sup><i>P1/P2</i></sup> ...
(A) Sleep profiles in R23E10>Dop1R1RNAi, flies and their parental controls R23E10/+, and Dop1R1RNAi/...