Macrophage labeling with fluorescent activity based probe.

<p>Ligated and control carotid arteries from mice treated with GB123 (<b>a</b>) or GB137 (<b>b</b>) (described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0160522#pone.0160522.g001" target="_blank">Fig 1</a>) were embedded in OCT and serial sectioned. Samples were stained for F4/80, a macrophage marker, and scanned by a confocal microscope: DAPI (blue), Cy5 labeled by probe (red), F4/80 (green), yellow color is overlay of red and green fluorescence. Cathepsin probes were found to co-localize with F4/80 macrophages.