Pharmacological inhibition of IGF1R restricts growth of a subset of human T-ALL cell lines.

<p>Cell growth as measured by resazurin reduction assay. Twenty-seven human T-ALL cell lines were cultured <i>in vitro</i> for 3 days with either (<b>A</b>) IGF1R blocking antibody (CP-751,871; 1 μg/ml) versus PBS vehicle control (mock) or (<b>B</b>) dual IGF1R/InsR tyrosine kinase inhibitor (BMS-754807; 0.5 μM) versus DMSO vehicle control (mock). Mean resorufin (reduced resazurin) fluorescence values +/- SD after normalization to mock-treated controls are plotted for assays performed in triplicate. Cell lines are rank ordered left-to-right by decreasing effect of the CP-751,871 blocking antibody. The horizontal dotted line indicates the 20% growth inhibition level.