Volume-weighted tissue blood oxygen saturations <i>Y</i> and hemoglobin concentrations (Case METAB).

<p>This figure is the analog of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0161267#pone.0161267.g009" target="_blank">Fig 9</a> for case METAB, using the same 90 vascular network realizations at <i>t</i> = 0 and <i>t</i> = 600 <i>h</i> as in case BASE. For each network realization at the end of the growth process, oxygen related parameters were simulated by randomly selecting <i>M</i>₀ from a lognormal distribution (see text). Fig 11A correlates tissue blood oxygen saturation in tumorous and normal tissue. In Fig 11B, tissue blood oxygenation is plotted versus tissue hemoglobin concentration for tumors (colored symbols) and normal tissue (black symbols) separately. The black lines in (A) represents the diagonal separating tumor data above from below normal. The color code to identify root node geometry is the same as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0161267#pone.0161267.g009" target="_blank">Fig 9</a>.