Additional file 1 of How time delay and network design shape response patterns in biochemical negative feedback systems

Supporting material. The file contains detailed stability analysis of Models 1-4; theoretical analysis showing how auto-inhibition increases τ m ; demonstration how τ m can be increased by auto-inhibition for the p53 model; details of robustness analysis of the optimal solution for the p53 model; modelling the switch from oscillatory to adaptive response of the p53 system; calculating the duration of “On” and “Off” states of p53 pulses; figure demonstrating the dependence between parameter values of Models 1-4 and τ m ; figure with results of Monte-Carlo analysis of Models 1-4 applied to the alternative parameter set; table with the best-fit parameters for the p53 model. (PDF 1044 kb