E-cadherin stabilization by p120ctn is required for proper polarization and cell–cell adhesion by EB cells.

<p><b>(A)</b> Confocal pictures of p120ctn and E-cadherin stainings of control and p120ctn^-/-;AL^tg/+ mESCs, and of p120ctn^-/-;AL^tg/+ mESCs expressing various rescue constructs from the R26 promoter, as indicated by the names above each of the images. An 2.9-fold magnified image is shown below each picture. Scale bars: 25 μm. <b>(B)</b> TEM of DIV12 EBs, control or p120ctn^-/-;AL^tg/+ EBs, or p120ctn^-/-;AL^tg/+ EBs expressing various rescue constructs from the R26 promoter, as indicated. Blue boxes depict areas with mature junctions while blue arrows denote areas of minimal cell–cell adhesion. Black scale bars: 10 μm; white scale bars: 1 μm.