Additional file 1: of Structuring evolution: biochemical networks and metabolic diversification in birds

(a) Appendix S1: Confirmed enzymatic reactions in the “avian space” of global carotenoid biosynthesis network in bacteria, plants, and animals. This appendix contains references supporting the presence of specific compounds and the enzymatic reactions that comprise the avian carotenoid biosynthesis global network. (b) Appendix S2: Characteristics of carotenoid metabolic networks for species used in the study. This appendix contains the structural measurements and references for compound identification and the method of identification for each of the species’ metabolic networks. (c) Appendix S3: Module assignments in the avian subset of the global carotenoid metabolic network. This appendix contains the module assignments for each of the compounds in the global avian carotenoid metabolic network. The number of the module corresponds to the partitioned regions in Fig. 2. (PDF 1501 kb