C3 breakdown products in RPE/Bruch’s are absent in <i>Cfh</i><sup>-/-</sup> mice but restored in the double knock-out <i>Cfb</i><sup>-/-</sup><i>/Cfh</i><sup>-/-</sup> mouse.
- Jennifer A. E. Williams (429778)
- Dimitris Stampoulis (3088713)
- Chloe E. Gunter (3088716)
- John Greenwood (429779)
- Peter Adamson (422257)
- Stephen E. Moss (208201)
Publication date
August 2016
DOIAbstract
<p>12 μm PFA fixed sections were taken of mouse retinas of indicated genotypes at 12 months. Sections were stained for C3b/iC3b/C3c (red) and nuclei (blue). Z-stacks were imaged using confocal microscopy and merged to form a maximum intensity projection (MIP). MIPs were merged with digital interference contrast and arrows highlight the presence of C3 breakdown products in RPE/Bruch’s. Scale bars = 50 μm. Images are representative of n = 6.</p
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