CD44 expression on T cells in mice lacking SOCS proteins.

<p>(<b>A</b>) Representative flow cytometry profiles of CD8 and CD44 expression on TCRβ⁺ T cells in spleens mice 14d after tamoxifen or vehicle treatment. (<b>B</b>) Proportions of CD8⁺ T cells expressing high levels of CD44 (CD44^hi) in spleens of mice at the times indicated after tamoxifen or vehicle treatment. (<b>C</b>) Proportions of naïve (CD44^- CD62L⁺), central memory (CD44⁺ CD62L⁺) and effector memory (CD44⁺ CD62L^-) CD3⁺ T cells in spleens of mice 50d (top panels) or 180d (bottom) after tamoxifen or vehicle treatment (m, moribund). Mean ± SD is shown with * p<0.05 for comparison of γ<i>S1S3</i> (moribund) with all genotypes at day 50 except γ<i>S1</i> (non-moribund day 50). ** p<0.05 for comparison of γ<i>S1</i> (moribund) with all genotypes at day 180 except γ<i>S1</i> (non-moribund, day 180), one-way ANOVA with Tukey’s multiple comparisons test, n = 7–20 mice per group.