Additional file 8: Figure S6. of Systemic inflammation disrupts oligodendrocyte gap junctions and induces ER stress in a model of CNS manifestations of X-linked Charcot-Marie-Tooth disease

LPS induced neuroinflammation does not cause blood brain barrier (BBB) disruption in Cx32 mutant mice. These are images of fixed coronal brain sections, immunostained with blood brain barrier markers fibronectin (green) (a-f) or fibrinogen (red) (g-l) and counter stained with DAPI (blue). There is no apparent disturbance of BBB integrity in the brain of LPS treated (b, d, f, h, j, l) compared to saline treated (a, c, e, g, i, k) mice from any of the three genotypes, as indicated. Linear fibrinogen immunoreactivity in brain parenchyma represents small blood vessels. Scale bar: 50Â Îźm. (TIF 9451Â kb