Neuropathological findings in Theiler’s murine encephalomyelitis virus (TMEV)-infected SJL mice.
- Ann-Kathrin Uhde (3110976)
- Vanessa Herder (289722)
- Muhammad Akram Khan (3110982)
- Malgorzata Ciurkiewicz (3110979)
- Dirk Schaudien (148946)
- René Teich (3110985)
- Stefan Floess (24038)
- Wolfgang Baumgärtner (148965)
- Jochen Huehn (8746)
- Andreas Beineke (201418)
Publication date
September 2016
DOIAbstract
<p>(A) Leukomyelitis in a TMEV-infected animal at 49 days post infection (dpi). Note perivascular and meningeal (arrow) infiltration of inflammatory cells within the white (*) and grey matter (#). H&E staining, bar = 60 μm. (B) Arginase-1<sup>+</sup> M2-type microglia/macrophages with gitter cell morphology at 49 dpi, indicative of myelinophagia. Immunohistochemistry, bar = 20 μm. (C) Bilateral loss (arrows) of myelin basic protein (demyelination) in ventral funiculi of a cervical spinal cord segment at 49 dpi., Immunohistochemistry, bar = 200 μm. (D) Axonal damage characterized by axonal swelling (spheroid formation) with accumulation of np-NF (arrow) in the spinal cord white matter at 49 dpi. Immunohistochemistry, bar = 20 μm.</p
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